- Enhances mood and neural function
- Promotes joint comfort and mobility
- Supports liver health and detoxification
Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
SAM-e (S-Adenosyl Methionine) is derived from the amino acid methionine and ATP (Adenosine Triphosphate). ATP is normally synthesized in the body but may become depleted from sickness and aging. SAM-e is concentrated in the liver and brain and has multiple mechanisms of action in the body. As a major methyl donor, it synthesizes hormones, nucleic acids, proteins, phospholipids, catecholamines, and other neurotransmitters.
Supplementing with SAM-e
The manufacturing process of SAM-e yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAM-e used in our SAM-e 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAM-e and Joint Function
In clinical trials, SAM-e has been shown to help reduce pain in joints and increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.
SAM-e and Mood and Cognitive Function
SAM-e’s ability to boost brain cell methylation facilitates youthful DNA enzymatic actions which may help account for its mood-elevating properties. These enzymatic actions are required for the healthy conversion of neurotransmitters, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body’s antioxidant defense and it helps maintain acetylcholine levels necessary for cognitive function.
SAM-e and Liver Function
In order to perform its detoxification role, SAM-e facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.
Suggested Use: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.